HIRONIC

The 7th edition of HIRONIC GLOBAL NEWSLETTER has been released. Please send an email to "marketing2@hironic.com" if you have any questions.Thank you   

JAPAN, TAIWAN, AND IRAQ – HIRONIC WELCOMES GLOBAL PARTNERS TO ITS MAIN OFFICE From August 9th to 10th, HIRONIC hosted yet another distributor training (HDT) event for its worldwide partners. This time around, the company was excited to welcome guests from Japan, Taiwan, and Iraq. HIRONIC’s Overseas Sales, Customer Service, and Global Marketing teams poured their efforts into crafting and delivering insightful content about the company’s flagship products. The first day was all about breaking down the technical and market appeal of both NEW DOUBLO and SILKRO (GENTLO), while the following day dove into the unique advantages of PICOHI. Each device was also demonstrated in action, showcasing the remarkable clinical effects of HIRONIC's equipment. HIRONIC is very pleased with the way the HDT sessions have been going so far and hopes to establish closer communication with all of its global partners. Parties interested in participating in the HDT event are encouraged to contact their local representatives. [HIRONIC Press Center]    

 HIRONIC HELD DISTRIBUTOR TRAINING EVENT IN JULY   On July 19-20, HIRONIC welcomed partners from Romania and Ukraine at its headquarters office for the Hironic Distributor Training (HDT) program. Medical aesthetics industry professionals participated, gaining insights into HIRONIC’s flagship products, including NEW DOUBLO, SILKRO (GENTLO), PICOHI, and DOUBLO GOLD. The program involved listening to lectures highlighting product strengths, real treatment results, and current trends in the medical aesthetics market, as well as having discussions with HIRONIC’s product experts. To enhance training efficiency, several hands-on treatment sessions were held for participants. On the final day of training, HIRONIC’s partners also shared their valuable opinions regarding the training program format and future partnership opportunities.   HIRONIC expresses its gratitude to its global partners for their active participation. With a continued focus on expanding into global markets, including Brazil, Western Europe, and Eastern Europe, HIRONIC plans to organize more similar events for its partners. As for the HDT program, the company intends to conduct several training sessions in the upcoming months. Interested parties are encouraged to get in touch with their local sales representatives for more information about the training program.     [HIRONIC Press Center] 

Special Edition of HIRONIC GLOBAL NEWSLETTER has been released. Please send an email to "marketing2@hironic.com" if you have any questions.Thank you  ​ 

The 5th edition of HIRONIC GLOBAL NEWSLETTER has been released. Please send an email to "marketing2@hironic.com" if you have any questions.Thank you   

ONLINE SEMINAR ON THE PICOHI AND NEW DOUBLO 2.0 WAS HELD FOR HIRONIC DISTRIBUTORS AND PROVIDERS IN JAPAN. ​

In the JUNE issue of D&PS, Korea's most recognizable aesthetic magazine, our KOL of V-RO LIFTING (export name: new doublo) spoke about the clinical effect of New Doublo.If you have problem in viewing this article, please check the attached document for original article and translated version.   Review: 2023 KALDAT (Korean Association of Laser, Dermatology and Trichology) Advanced Beauty Medical Device Expo and Spring International Academic Forum Synergistic Effect for Facial Lifting of MFU and RF Combined Technology Lecture / GeeBum Kim (Finance Director, KALDAT)  On April 23rd, the 2023 KALDAT (Korean Association of Laser, Dermatology and Trichology) Advanced Beauty Medical Device Expo and Spring International Academic Forum were held at COEX Hall C. This event was planned as a place where various people involved in aesthetic medicine could naturally harmonize, and at the same time, it was prepared as a venue for communication in aesthetic medicine by inviting the Seoul Metropolitan Government Deputy Mayor and members of the National Assembly to examine current issues related to medical policy. In addition, through the slogan of ‘Leaders’, the executives and members of KALDAT made it clear that they were leading Korea’s aesthetic medicine with effective and safe techniques in the clinical field. In this issue, we introduce GeeBum Kim, KALDAT (Korean Association of Laser, Dermatology and Trichology) Dr. GeeBum Kim from Korean Association of Laser, Dermatology and Trichology, emphasized that the development of cosmetic medicine has been achieved in a way that reduces downtime and pain while showing satisfactory effects, and that this should be taken into consideration in setting up protocols. Less Adverse Event, More Dramatic Result Among the areas of cosmetic medicine, skin rejuvenation · lifting · tightening can be explained in a similar category. Representative mechanisms that encompass this are RF and HIFU. This lecture will focus on Hironic's V-RO LIFTING (Export name: New Doublo). V-RO LIFTING (Export name: New Doublo) is a little unique device. It implements RF and HIFU almost simultaneously. In the past, RF and HIFU were treated with different devices, but V-RO LIFTING (Export name: New Doublo) can achieve various treatment effects at once without a time difference. As far as I know, it is the only device that shows RF and HIFU at the same time. Just as there was a time when peeling procedures were mainly performed, aesthetic medicine developed dramatically with the appearance of Fractional Laser, RF, and HIFU. The key to this development is the reduction of downtime and pain. Most of the new mechanisms were painless, and it was possible to return to daily life immediately after the procedure. Recently, a lot of research on appropriate thermal energy and appropriate thermal temperature has been conducted, and parameters for each mechanism are being improved and established. In other words, the demand for ‘less adverse event, more dramatic result’ is increasing in ‘high-risk, high-return’. Even plastic surgeons are increasing the proportion of minimally invasive procedures such as fillers and botulinum toxin. Of course, thread lifting is a bit more aggressive than that. Like this, what is needed for ‘less adverse event, more dramatic result’ is combination therapy. I think that one of the main combinations in this combination therapy is RF and HIFU. In actual clinical settings, lasers are added here, and if cold rejuvenation is to be emphasized more, drugs such as skin boosters are injected in parallel. (Figure 1) is an image often mentioned when explaining the classical laser theory. In the past, we have focused on the area of protein coagulation. It is said that even with HIFU, the temperature can be raised by more than 60℃. I don't know if that actually happens. Of course, I don't know if I can do stacking hard on the spot, but I don't know if it will have any effect other than the fat melting procedure. So, recently, I am focusing on targeting a slightly lower temperature for treatment. Rather than protein degradation, we care about the region where reversible change takes place, and we are even more interested in the photoactivation region. The photoactivation area is not limited to laser treatment, but I think that you can get an idea from photo-activation when setting the parameters of all EBD (Energy Based Device).​  (Figure 1). Range of typical bioreactions associated with a surgical laser and their approximate temperature range. Source: Is Light-Emitting Diode Phototherapy (Led-Lllt) Really Effective?.,Wonseok Kim etc., Laser Ther. 2011; 20(3): 205–215., doi: 10.5978/ islsm.20.205.   Considerations for HIFU procedure As is widely known, ultrasound uses waves of a certain frequency or higher or physical properties. Largely, it shows effects such as mechanical effect, cavitational effect, and thermal effect. Although there are differences in the degree of these three effects, it can be considered that they occur simultaneously in terms of time. Unusually, you can also find research related to pigment treatment through HIFU, which emphasizes the cavitation effect more. Even in ultrasound, there is talk of impedance. Ultimately, the speed varies depending on the medium, and biological reactions appear at the interface of the medium. B The percentage of reflection between one fat (49%) and soft tissue-air (99%) is high. If the density and propagation speed of the two tissues in vivo are the same, there is no ultrasonic reflection at the interface, but the density and propagation speed are different. This is because reflection occurs at the interface between tissues with different impedances. These are the points where side effects occur most frequently during treatment in actual clinical practice. HIFU is formed in different forms of energy according to the diameter and curvature of ceramics for each device. The thesis participated by several executives of the evacuation cap informs that the form of energy was different when the energy was investigated for each HIFU. It can be seen that there are more suitable types for each purpose of the procedure. It would be a little more useful if you know that the ceramic shape shows the characteristics of each device, just like a human fingerprint. The advantage of HIFU is that it does not react to chromophores. Therefore, compared to other mechanisms such as lasers, it can be usefully used by Asians as well. There is almost no downtime, and the clinical effect is immediate. Poor contact between the tip and skin, excessive staking, or narrow spacing may cause side effects such as burns, ball pits, and nerve damage. V-RO LIFTING (Export name: New Doublo) has a special sensor attached to the tip, and it is set so that the shot itself is not irradiated if the grounding is not correct. The device stops if it determines the amount of illumination in the tip and determines that the environment is not suitable. If you are familiar with HIFU procedures, it may not be very necessary, but personally, I still turn on this sensor and perform the procedure. I think it is one way to maintain the consistency of the procedure.   When performing HIFU treatment, it is difficult to decide which layer to target. On which floor and at what temperature will the procedure be performed? How to treat patients with reduced volume or patients with sagging? How to do patient selection? However, most patients do not visit the hospital only with one specific concern. In the end, problems come in a mixed form, so you need to think about which mechanism to use in parallel. Several studies that have analyzed concurrent treatments show that the last procedure has a better effect. For example, if you want to reduce the volume, it means that you should do RF first and then HIFU.​ Then, what would be the result of the procedure with almost no time difference? Hironic recently analyzed the synergistic effect of RF and HIFU combined treatment compared to HIFU alone at the Human Skin Clinical Trial Center. It is effective for various indications, but interestingly, it is said that the effect of improving pores is very large. The hospital also makes and operates a separate pore program using a 1.5mm tip, and the satisfaction of patients is very good. Existing pore programs had many parts in the form of ablation, but since it can increase the effect non-ablatively, it might be worth considering. If you apply ultrasound gel during the procedure, the skin's outer moisture will naturally improve, but V-RO LIFTING (Export name: New Doublo) is also effective in improving the inner skin's moisture. The skin texture improvement effect is also positive. V-RO LIFTING (Export name: New Doublo) is used a lot in pigment treatment. The cavitation effect described above has an effect, and it seems to be helpful to restore the skin barrier and make the dermis healthy. In fact, it is convincing in light of the fact that the moisture inside the skin has improved. It can be said to be an attractive device that can be used in a variety of ways, from skin rejuvenation, lifting, and tightening to pigment treatment.​​​

HIRONIC has published the interview about PICOHI, and also advertised PICOHI and SILKRO on The Aesthetic Guide May/June Issue. Please click the linlk below to see the full article!https://www.flipsnack.com/theaestheticguide/mayjune2023/full-view.html   

  Hironic Co., Ltd. (CEO Kwon Geum-Lye) won the grand prize in the beauty and medical device category at the Money Today '2023 Consumer Satisfaction Awards' held at the Korea Press Center in Jung-gu, Seoul on the 27th. The 'Service Customer Satisfaction Grand Prize selected by consumers' is an award given to companies that discover promising service companies in each field of the next generation and realize customer satisfaction.  HIRONIC's mission is an abbreviation of High Electronic, meaning that it will supply products with high technology to the market. In fact, Hironic launched Doublo, the first in Korea and world's second HIFU (High-intensity focused ultrasound) lifting equipment, and the world's first 4th generation HIFU + RF combined equipment V-RO LIFTING (Export name: New Doublo) and 'PICOHI300' that realize stable 300ps, etc., receiving many love calls from medical staff and consumers, leading the technology within the market. In addition, HIRONIC's management philosophy and slogan are 'Happy Maker, HIRONIC, a company that creates a happy world', which implies that it will improve the quality of life and contribute to creating a happy world with a beautiful and confident appearance. An official from Hironic said, “We feel a great sense of responsibility for winning the award for six consecutive years, and we will continue to strive to maintain customer satisfaction through differentiated concept products and customer-oriented services.” Also, "Sales are increasing with our flagship products 'Vrolifting' (Export name: New Doublo) and 'PICOHi', which are continuously loved, and we expect steady growth through new products to come in the future," 

 Hironic Co., Ltd., a company specializing in manufacturing skin beauty medical devices, announced on the 31st that it had appointed Executive Director Geum-Lye Kwon as the new CEO through a board meeting.Geum-Lye Kwon​, the new CEO, was born in 1966, graduated from the Department of German Language and Literature at Sogang University, and obtained a master's degree through the MBA course at Sogang University. According to Hironic, Geum-Lye Kwon​, the new CEO, has worked for four global companies over 30 years, learning advanced global management and driving various growth. After leading cosmetics brand marketing at Johnson & Johnson Korea and Beiersdorf NIVEA, and leading various business units at leading medical device companies Smith & Nephew and BECTON, DICKINSON AND COMPANY, then she joined Hironic as executive director in January this year.​​​​Through this, based on the experience of new CEO Keum-Lye Kwon in the cosmetics and medical device marketing business for more than 30 years and the experience of developing a brand with an annual growth rate of over 67% and a single product sales of over 10 billion won during her tenure as a group brand manager, she explained that she will play the role of a stepping stone to reach customers through differentiated marketing for products with technological prowess.  Geum-Lye Kwon​, the new CEO, said, “As the COVID-19 era passes and customer needs for Hironic products increase, we establish a customized strategy and develop tactics that make our products more easily understood by customers and feel necessary for customers". He also expressed his ambition, saying, "We will prepare a marketing program that makes it easier and easier for ordinary customers to use and treat our products that have high entry barriers and require expertise, and be reborn as skin care products that meet various age groups." Meanwhile, in March, Hironic signed a medical device supply contract worth 7.5 billion won with local distributor MEDPRO to enter the Brazilian market.​ 

​The 3rd edition of HIRONIC GLOBAL NEWSLETTER has been released. Please send an email to "marketing2@hironic.com" if you have any questions.Thank you   

 In the March issue of D&PS, Korea's most recognizable aesthetic magazine, our KOL of V-RO LIFTING (export name: new doublo) wrote about the clinical effect of New Doublo.If you have problem in viewing this article, please check the attached document for original article and translated version.   V-RO LIFTING (Export Name: New DoubloTM)​Synergy Effect of HIFU+RF Jang Hyoseung MD (Director of Forever Clinic, Incheon Bupyeong branch, Korea)   The link between lifting the mandate to wear masks indoors and the increase in demand for skincare is difficult to explain in theory. However, people who have had skin problems due to wearing masks for a long time might have an experience to seek out skin treatments to solve these problems. In addition, the desire to improve the appearance of individuals due to society-wide lookism is raising expectations for the increase in demand for skincare treatments, which have been stagnant for a while. The negative effects of long-term mask wear on the skin can be summarized as follows. ① Acne: Wearing a mask creates a warm and humid environment, which increases sebum production, which can lead to acne. It is so common that the new word "maskne," which means acne rash caused by wearing a mask, has emerged. ② Stimulation and rash: the constant friction and pressure of the mask on the skin causes irritation and rash, especially in areas where the skin is already sensitive, such as around the mouth and nose.  ③ Dry skin: Wearing a mask reduces the amount of air that reaches the skin, causing moisture loss. To mitigate these effects, it's important to practice good skin care habits, such as keeping your skin clean, hydrating and protecting, and adjusting your mask appropriately to reduce friction and pressure. However, if skin irritation or other problems arise due to prolonged wearing of masks, it is recommended to see a dermatologist in the end. Even though the four-year mask mandate has been lifted, it is still said that wearing masks are more comfortable than bare faces, but changes in the lifting of masks are slowly being observed in the field. CLINICAL EVIDENCE FOR V-RO LIFTING (Export Name: New DoubloTM) The combination of HIFU and RF was already an excellent aesthetic procedure that had become a trend even before the COVID-19. However, in order to receive two different treatments at once, there was a burden such as the inconvenience of spending a long time at the hospital and the high cost of the procedure. V-RO LIFTING (Export Name: New DoubloTM) emerged in August 2021, amid the recession of COVID-19 to improve this inconvenience, and its usefulness has been widely publicized within the conference even under difficult circumstances.   New products are often shunned in the market due to a lack of clinical evidence. However, V-RO LIFTING was securing trust in its effectiveness as clinicians shared their experience of use. In the midst of the COVID-19, it was proved that combined use of HIFU and RF is superior than HIFU alone in effectiveness through its own human trials. The synergy effect of HIFU+RF was also demonstrated in thermal imaging camera observation performed by HIRONIC. As a result of measuring the surface temperature of each skin after performing the procedure with the same energy value in Split face, the thermal response of the area was higher in the case of HIFU+RF. (Image 1)     <Image 1.> Skin surface temperature measured by thermal imaging camera: simultaneous HIFU+RF vs. HIFU only. (Sources: HIRONIC)  <Image 2.> Tissue change before and after HIFU + RF irradiation on the back of the micro pig (x50)>  A: Before HIFU+RF irradiation (H&E stain)  B: After HIFU+RF irradiation (H&E stain), The darkened red color due to collagen regeneration  C: Before HIFU+RF irradiation (MT stain)  D: After HIFU+RF irradiation (MT stain), The darkened blue color due to elastin activation   In addition, in order to confirm the clinical improvement due to higher thermal response, HIFU + RF was irradiated on micro-pigs, the most similar to human skin, and it was confirmed that both collagen and elastin were activated (Image 2) Through H&E (Hematoxylin and Eosin) and MT (Masson's Trichrome) staining, the activity of collagen and elastin, which is key indicators related to skin elasticity, could be observed more clearly.   H&E staining, which darkens pink as collagen activity increases, and MT staining, which darkens blue with increased elastin activity, both were deepened where simultaneously irradiated with HIFU and RF (Image 3).     Based on these results, human clinical trials were conducted, and a significant improvement in various indicators related to skin beauty was found compared to HIFU alone.    <Image 3> Collagen and elastin activation proved in pre-clinical trials: HIFU+RF vs HIFU. (Source: Hironic)   Compared to HIFU alone, HIFU+RF combined treatment achieved faster and higher improvement and lasted longer.   The average depth of eye wrinkles decreased by up to 1.6 times and, the treatment effect was maintained for over 8 weeks. In addition, the pores that determine the overall skin tone and impression were also very improved.  <Image 4> Comparison through nasolabial imaging: HIFU+RF vs. HIFU (Source: HIRONIC)<Table 1> Average depth difference in nasolabial line (Source: Hironic)  <Image 5> Comparison through periorbital area imaging.    <Table 2> Average depth difference in periorbital line (Source: HIRONIC)   The combined HIFU and RF treatment showed excellent pore improvement after the first treatment. Compared to HIFU alone, pore density was increased by up to 9.0 times, the number of pore was decreased by up to 13.3 times, and this treatment effect was maintained for over 8 weeks <Image 6> Comparison through pore imaging (Source: HIRONIC)   It was confirmed that the treatment results were overally improved in a total of 14 items, and it was observed that there was a remark difference in number of pore, pore density, and inner skin moisturizing of an average of 1.2 ~ 4.8 times and a maximum of 1.4 ~ 13.3 times.​ <Table 5> Skin improvement rate. HIFU+RF vs. HIFU (Source: HIRONIC)   REASON FOR RECOMMENDATION   Although support from large clinical trials may provide clear reasons, it can be assumed that this improvement is due to the activation of glycosaminoglycans (GAGs) by RF.   There are a total of six GAGs (hyaluronic acid·chondroitin sulfate · dermatan sulfate · heparan sulfate heparan sulfate · heratan sulfate) that exist on external surface of cell membrane or outside of cell and play an important role in forming a fiber structure by bridged bond with collagen and elastic fiber molecules in a certain space.   Since GAGs has the ability to bind to water molecules more than 1,000 times its molecular weight, it can be hypothesized that GAGs could have observed this conclusion because it holds water molecules in the skin, inhibiting the skin's water retention and the degradation of collagen and elastic fiber molecules. V-RO LIFTING (Export name: New DoubloTM) has now secured not only word of mouth but also trust through human clinical trials. In addition, as a differentiation strategy that can break through the limitations of energy devices, it is a satisfactory device in many aspects such as effectiveness, safety, and reasonable treatment cost.   Since two procedures can be performed at once, the burden of cost and treatment time have been greatly reduced. In addition, considering that it is equipped with a patented safety sensor so that there is no worry about burns, it is recommended to introduce V-RO LIFTING (Export name: New DoubloTM) that can lead to improved satisfaction with patients' procedures and increased visit rates.   <Image 7> Synergy effect of HIFU and RF proved through human clinical trials (Source: HIRON <Image 8> Structure and type of glycosaminoglycan. Scheme showing some proteoglycans and other GAGs (Glycosaminoglycan Chains) of the extracellular space. (Source: https://international.neb.com/applications/glycobiology-and-proteomics/recombinant-glycoprotein-expression/glycosaminoglycan-chains-gags.)  

HIRONIC participated in KIMES 2023, which was held in Seoul, Korea.  We exhibited the advanced NEW DOUBLO 2.0, SILKRO and PICOHI 300. About 1,000 people visited our booth and there was a great deal of interests on our products from dermatologists, distributors and relevant businessmen.  

HIRONIC participated in COSMOPROF Bologna 2023, which was held in Bologna, Italy.  We exhibited NEW DOUBLO, ERIGE and PLASONIC. Many people visited our booth and showed a great interest on our products.  

HIRONIC participated in AAD 2023, which was held in New Orleans, LA, USA.  We exhibited NEW DOUBLO 2.0, SILKRO, SLIMUS and PICOHI 300. We were really excited to introduce HIRONIC’s new product “NEW DOUBLO 2.0” to booth visitors. Many people visited at our booth and enjoyed “TOOHO”, one of KOREAN traditional game.  ​